Electronic Supplementary Information (ESI) for Chemical Communications
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چکیده
Reagents. β-D-(+)-glucose, ascorbic acid (AA), uric acid (UA) and p-acetamidophenol (AP) were purchased from Sigma and used as received. Porous anodic alumina (PAA) membranes with the pore sizes of 20 and 100 nm were from Whatman Corporation. The quoted pore diameters of the PAA membranes were 20 and 100 nm, but actually, according to the SEM image of the PAA membrane, there was a pore diameter distribution mainly in the range of 40-60 nm and 150-220 nm, respectively. PdCl2 was purchased from Shanghai Chemical Reagent Co. Polyvinyl alcohol (PVA, average degree of polymerization, 1800±100) was purchased from Shanghai Laize Factory of Fine Chemicals. Phosphate buffer solutions (PBS, 0.1 M) with various pH values were prepared by mixing stock standard solutions of K2HPO4 and KH2PO4 and adjusting the pH with H3PO4 or NaOH. All other chemicals were of
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Development and substrate specificity screening of an in vivo biosensor for the detection of biomass derived aromatic chemical building blocks† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6cc04559f Click here for additional data file.
Measuring substrate and/or product concentration can create a major bottleneck for synthetic and biosynthetic processes. Here we report the development and substrate screening of a whole cell biosensor to detect biomass-derived aromatic chemical building blocks, supporting the use of sustainable feedstocks in the bulk and fine chemical industries.
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Oligobenzamide inhibitors of the p53-hDM2 protein-protein interaction are described.
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The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.
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Ramariolides A-D are natural products with antibacterial activity. To exploit their cellular mechanism, we here devise the first total synthesis and prepare a photoprobe for target identification. Antibacterial testing against several pathogenic strains including Mycobacterium tuberculosis revealed the highest potency for ramariolide A. Chemical proteomics unraveled binding to essential protein...
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Peptides and proteins fragment sequence-specifically in the presence of 3-mercaptopropionic acid to afford thioesters which can be used in native chemical ligation reactions.
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The oxidative addition of Csp(2)-Br or Csp(2)-I bonds to gold(I) does not take place even under very favorable intramolecular conditions that could form five- or six-membered gold(III) metallacycles. DFT calculations reveal that although this process could be feasible thermodynamically, it is kinetically very sluggish.
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